Bath doctor to lead £2.1m UK Parkinson’s trial

A Bath doctor has been chosen to lead a £2.1m UK-wide trial into Parkinson’s disease.

Dr Emily Henderson, a geriatrician at the Royal United Hospital in Bath and an honorary senior lecturer at the University of Bristol, will be in charge of the three-year study, which will recruit 600 patients across 26 UK hospitals.

The aim of the study, which is due to begin in early 2019, is to determine whether a drug known as a cholinesterase inhibitor (ChEi) will help people with Parkinson’s.

The trial – jointly run by the Royal United Hospitals Bath NHS Foundation Trust and the University of Bristol – is possible following a multi-million pound grant from the National Institute for Health Research (NIHR), the research arm of the NHS.

A trust spokesperson said: “It will test whether a commonly prescribed dementia drug could prevent debilitating falls for people with the disease. Falls are a frequent complication of Parkinson’s, which affect around 60% of the 127,000-people diagnosed with the condition each year.

“With the degeneration of dopamine-producing nerve cells, people with Parkinson’s often have issues with unsteadiness when walking. As part of the condition, they also have lower levels of acetylcholine, a chemical which helps us to concentrate – making it extremely difficult to pay attention to walking. The combination of both often leads to patients suffering from injuries, broken bones and hospital admission.”

The spokesperson added that the trial follows on from earlier phase trials which showed that cholinesterase inhibitor treatment has potential to almost halve the number of falls and improves the regularity of walking, speed, and balance.

Dr Henderson said there is an urgent need to identify treatments that reduce falls in Parkinson’s disease.

She added: “As the population ages, the number of people living with Parkinson’s disease and the occurrence of complications will increase. This trial will provide definitive evidence as to the role of ChEi for falls.

“If successful, this treatment will improve the lives of people living with Parkinson’s now and has the potential to be tested in other groups of patients who are at high risk of falling. We are working hard to tackle one of the most disabling complications of Parkinson’s.”

Trial patients will be randomly assigned a 12-month course of either a cholinesterase inhibitor via a patch or a placebo (dummy) treatment. However, neither the researchers nor the participants will know which group they are in. Patients will be asked to record any falls that they experience in diaries that they post back each month for a year.

Findings from the trial, funded by the NIHR Health Technology Assessment programme, will be published in a research journal.

Tim Craft, the trust’s director of research and innovation, said being involved in such a high calibre of research was good for the trust, and enhanced its reputation and income.

He continued: “I am delighted to say that we have been awarded this very important grant. This is a really exciting time for the trust to be increasing its participation in research, with the UK government supporting the growth of life sciences research with significant additional funding.”

For further information about the trial email: chief-pd@bristol.ac.uk.

The Editor

Hello! I'm KATE, a journalist, editor and broadcaster with 20 years experience in the industry. I have worked at the BBC, ITV, Heart and Sky Sports News. I've lived in Somerset for most of my life and set up LOVE SOMERSET ONLINE in 2016. I love the seaside and am partial to a good gin and tonic.

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